The centre was originally founded at Sotik as an experimental station to conduct research on aspects of animal and crop husbandry. The station was relocated to its present location in 1963, with a mandate to conduct general field investigations in South Nyanza region. In 1968, the name of the station changed to Nyanza Agricultural Rsearch Station with an expandeated mandate area that included Central Nyanza District. In addition, Kilgoris/Ang’ata Baragoi areas formerly in Narok District were added in in 1977 and the scope of the work expanded. By 1983, Kisumu and Kericho were Districts were added to the mandate are and the station renamed Regional Rserach Centre (RRC), Kisii. It has now changed its name to FCRI, Kisii with a mandate of Four counties namely Kisii, Nyamira, Homa bay and Migori
The KALRO FCRI, Kisii is one of the Food Crops Research Institute centres located along the Kisii-Kericho road, about 3 km from the Kisii town centre. It is on latitude 0o 41’S and longitude 34o 47’ E. It is situated at an altitude of 1806 m above sea level (asl) in the upper midland (UM1) agro ecological zone (AEZ)
It has a bimodal rainfall with an annual average of about 2100 mm and temperatures ranging from 15 – 25o C.
The centre has two sub centres;
- HomaBay sub centre that is located in HomaBay FTC in HomaBay town. It is situated at an altitude of about 1140 m asl in AEZ LM 3-4. Average rainfall is 800 – 1000 mm with an annual mean temperature of 22.7o C.
- Oyani sub centre that is situated within the Oyani Animal Improvement Centre in Migori District. It is located in AEZ, UM2-3 at an altitude of 1450 m asl. It receives bimodal rainfall with an annual average of 1600 mm and has an annual mean temperature of 21.10 C.