The core business of the institute is research geared towards alleviating the impact of livestock diseases and thus contributing to reduction of poverty and improvement of livelihoods and food security in Kenyan households. Priority diseases in the country include Foot and mouth disease (FMD), tick-borne diseases (East Coast fever, Anaplasmosis, Babesiosis, Heartwater), rinderpest-like diseases (malignant catarrhal fever, bovine viral diarrhoea and peste des petits ruminants), contagious bovine and caprine pleuro-pneumonia (CBPP), capripox virus infections, trypanosomiasis and helminthosis.  The Institute also addresses aspects related to development and validation of novel livestock vaccines. It is estimated that 75% of the pathogens that afflict humans originate from animals, both wild and domesticated. Animal health research will of necessity have to embrace multi-disciplinary approaches in order to have positive contributions to human, animal and environmental health. Packages for management and control of these diseases undergo adaptive research to validate their effectiveness in various agro-ecological zones and livestock production systems